What is the recommended initial GIR for pre-term and term infants?

The recommended initial glucose infusion rate (GIR) for both pre-term and term infants is typically between 6-8 mg/kg/min. This rate is significant because it helps to ensure adequate glucose supply to the infant's brain and body during a critical period of growth and development. Newborns have limited glycogen stores and may be at risk for hypoglycemia, especially if they are pre-term or if there are additional metabolic stressors. Starting within this range provides sufficient energy and minimizes the risk of fluctuations that could lead to adverse outcomes.

Infants, particularly those who are preterm, require careful management of their glucose levels to prevent complications associated with both hypoglycemia and hyperglycemia. The 6-8 mg/kg/min range strikes a balance, allowing the body to utilize glucose effectively without overwhelming immature metabolic systems. While higher rates are sometimes used in specific clinical situations, the initial GIR typically starts at this level to monitor for the infant's response and adjust as necessary based on their clinical condition.