What is the minimal enteral nutrition volume at which PN should not be used for preterm infants?

In the context of nutrition for preterm infants, minimal enteral nutrition is important for stimulating gut development and function. The threshold where parenteral nutrition (PN) should not be used is established based on the volume of enteral nutrition that can be safely administered.

When considering the choice of 100mL/kg/day, this volume is recognized as sufficient to promote gastrointestinal health and to meet the minimal needs of preterm infants without relying solely on parenteral nutrition. At this volume, enteral feeds provide an adequate stimulus for the gastrointestinal tract, thereby encouraging physiological developments and reducing the risks associated with prolonged PN, such as infection and metabolic complications.

In practice, administering at least 100mL/kg/day of enteral nutrition can help in transitioning infants towards full oral intake and supports their growth and development. This volume is a practical standard that helps healthcare providers make decisions regarding the nutrition of preterm infants. Lower volumes may not adequately support the infant's metabolic needs or intestinal acclimatization, while higher volumes may be beyond what an immature gut can handle initially. Thus, the choice of 100mL/kg/day stands as a clinically recognized guideline in the management of preterm infant nutrition.