The prevalence of bone disease in CF patients increases with what factor?

The prevalence of bone disease in cystic fibrosis (CF) patients is significantly affected by the severity of lung disease and malnutrition. In CF, the body struggles with the production of digestive enzymes that are essential for nutrient absorption. This malnutrition can lead to deficiencies in key vitamins and minerals, including vitamin D and calcium, which are critical for maintaining bone health.

Additionally, the chronic lung infections and inflammation associated with the severity of lung disease contribute to an overall increased metabolic demand on the body. This, combined with decreased physical activity due to respiratory issues, can further exacerbate the risk of developing osteoporosis or other bone diseases.

In summary, both malnutrition, stemming from pancreatic insufficiency and related complications, and the impact of severe lung disease create a perfect storm that increases the likelihood of bone disease in patients with CF. Thus, the connection between these factors and the prevalence of bone disease is well-established in clinical practice and research.