In cholestatic disease, what substances are poorly excreted in the bile?

In cholestatic disease, there is a disruption in the normal flow of bile, which can lead to the impaired excretion of bile acids. Bile acids are critical components of bile that facilitate the digestion and absorption of dietary fats and fat-soluble vitamins in the intestines. When cholestasis occurs, it can result in elevated levels of bile acids in the liver due to their inadequate removal from hepatic circulation. This accumulation can contribute to liver damage and other systemic effects.

The other substances listed—glucose, lactate, cholesterol, bilirubin, electrolytes, and amino acids—are typically not the primary substances affected in terms of excretion during cholestasis, making bile acids the correct focus in this scenario. Cholesterol and bilirubin can be impacted in terms of their levels in the body, but the direct consequence of cholestatic disease specifically highlights the excretion issue related to bile acids, which is critical for understanding the pathology of the disease.