Excessive GIR may lead to which of the following conditions?

Excessive glucose infusion rate (GIR) can lead to hyperglycemia, which is characterized by elevated blood glucose levels. When the body is presented with large amounts of glucose, particularly through intravenous glucose administration, it exceeds the body's ability to utilize or store that glucose efficiently. This results in excess glucose remaining in the bloodstream, leading to hyperglycemia.

In pediatric patients, particularly those who are critically ill or have impaired insulin secretion or sensitivity, high rates of glucose administration can overwhelm their metabolic capacity. The body responds to this influx of glucose by working to secrete insulin; however, if the rate of infusion is too high and consistent, the insulin response may not be sufficient to manage blood sugar levels effectively.

This situation highlights the importance of monitoring glucose administration carefully, especially in vulnerable pediatric populations, to prevent complications like hyperglycemia, which can have serious health implications if not managed appropriately.